ABSTRACT

Basic Information

Abstract Number: 900 - 4
Author Name: Michael J Sailor - University of California - San Diego
Session Title: Pittsburgh Analytical Chemistry Award
Event Type: Awards
Event Title: Micro-and Nanoparticles of Porous Silicon as In-Vivo Diagnostic and Therapeutic Agents

Presider Name:Jane Chan
Affiliation:Bechtel Bettis, Inc.

Date: Tuesday, March 19, 2013
Start Time: 08:45 AM (Slot #4)
Location: 114

Abstract Content

Nanotechnology has created new opportunities in medicine that often arise from the unique combinations of nanoscale material properties that can be achieved. This presentation will describe self-destructing inorganic nanoparticles based on a non-toxic porous silicon scaffold. The material allows a modular approach to the design of imaging or therapeutic agents, which includes features such as: intrinsic photoluminescence; singlet oxygen sensitization; capacity for a wide range of payloads such as magnetic nanoparticles, large proteins, or oligonucleotides; tunable degradation rates; and large external surface to provide multivalent targeting. Porous silicon is a nanostructured material prepared by oxidation of single crystal silicon in the presence of HF (Figure). The electrochemical preparation conditions allow the precise tuning of pore diameter and pore wall thickness, which impact both the degradation and drug release characteristics. This presentation will discuss the synthesis and properties of microparticles and nanoparticles of porous silicon. Luminescent nanoparticles constructed from silicon offer a non-toxic alternative to Cd-based quantum dots. In particular, porous silicon nanoparticles have been shown to be biodegradable and to safely image tumors and organs in live animals. The addition of a targeting ligand that selectively interacts with tissues can improve the efficacy of imaging or drug delivery. The use of the magnetic, photoluminescence, and reflective optical characteristics of this material for in-vitro and in-vivo sensing and imaging will be highlighted.



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