Basic Information

Abstract Number: 1620-18     Author Name: Kevin P Menard Affiliation: PerkinElmer LAS Session Title: Materials Characterization Event Type: Poster Event Title: Combined DSC-Raman for Enhanced Materials and Pharmaceutical Characterization Presider(s):   Start Time: ( Slot # 18 ) Date: Tuesday, March 10th, 2009 Location: Keywords: Pharmaceutical, Polymers & Plastics, Raman, Thermal Analysis

Co-Authors

Name Affiliation Alexander, Robert PerkinElmer LAS Salamon, Andrew Walker PerkinElmer LAS Spragg, Richard PerkinElmer LAS Ye, Peng PerkinElmer LAS

Abstract Content

We describe a combined system for Raman spectroscopy and power compensated Differential Scanning Calorimetry (DSC). DSC is widely used to investigate phase changes of materials as their temperature is changed, or isothermally. However the information obtained is essentially quantitative as this is a univariate technique that simply measures heat flows. Vibrational spectroscopy can provide complementary information, giving insight at molecular level.into the changes accompanying thermal events or reactions. In addition the multivariate nature of Raman spectra means that it is possible to monitor simultaneous events with different spectral signatures that cannot be distinguished by DSC. Although both techniques are commonly applied to the same problem, simultaneous measurements have rarely been reported. This is probably due to the influence of the energy of the laser on the sample and power compensation DSC's ability to control temperature represents an advantage. We illustrate applications with examples of phase changes and reactions of polymers and pharmaceutical materials.