Basic Information
Abstract Number: 160-8    
Author Name: Brian Everatt Affiliation: Novartis
Session Title: High-Throughput Chemical Analysis
Event Type: Oral
Event Title: A 'Virtual' Analytical Instrument in Every Laboratory
Presider(s): Lynch, Garry J Start Time: 03:35 PM ( Slot # 9 )
Date: Sunday, March 11th, 2012 Location: 310B
Keywords: Analysis, Automation, Laboratory Automation, Sample Handling/Automation

Co-Authors
NameAffiliation
Tullett, SimonTTPLabTech

Abstract Content
Currently open access submission of chemical and biological samples to analytical equipment such as HPLC and LC-MS requires substantial manual investment. Typically medicinal chemistry samples are submitted for reaction monitoring, purity confirmation and final compound analysis; processes which can be a time consuming, error prone and inefficient.

We have carried out modelling studies on the submission of samples to instrumentation, observed patterns of behaviour, and generated mean values for the time taken for analytical data to be returned to the submitter.

We describe a novel approach to submitting and transporting samples for analysis across an entire site. Sample vials are registered and methods selected, an Electronic Laboratory Notebook (ELN) reference is assigned and the sample is placed into the “Sender”. The system then transports the samples using low pressure compressed air and directs them to the most appropriate analytical instrumentation available. The analytical results are then automatically returned to the originators ELN.

This presentation will describe the system recently installed at Novartis, Horsham (UK) and demonstrate the typical throughput capability and time savings this introduces to the users. A statistical analysis of the metrics generated shows how it is possible to rationalize expensive equipment, reduce the cost of maintenance and support whilst increasing availability. It will show how the system can cope with failure of the analytical instrumentation by being able to redirect samples to working equipment, and the potential for future expansion.