Basic Information

Poster Number: 860-2     Author Name: William J Long Affiliation: Agilent Technologies Session Title: Pharmaceutical LC, HILIC and GPC I Event Type: Poster Event Title: Compendial Methods Adjusted to Use Non C18, or Non Reverse Phase with Superficially Porous Columns Presider(s):   Start Time: ( Slot # 2 ) Date: Monday, March 12th, 2012 Location: Red Area on Exposition Floor, Aisles 1300-1500 Keywords: Chromatography, Drugs, HPLC, Liquid Chromatography

Co-Authors

Name Affiliation Joseph, Maureen Agilent Technologies Link, Jason Agilent Technologies Mack, Anne Agilent Technologies

Abstract Content

Higher productivity is the new catch phrase in pharmaceutical and other industries. One way to meet this demand is utilizing Superficially Porous HPLC columns such as Poroshell 120 into Compendial methods. These 2.7 um particles show comparable efficiency to sub 2 micron particles with about half the back pressure. Columns packed with these materials can be used in older HPLC instruments or in new higher pressure instruments for high resolution in longer column format. Previous work has utilized C18 reverse phase chromatography. In this work USP (United States Pharmacopeia) methods for generic pharmaceuticals will be adjusted to use non C18 Superficially Porous Columns or non reverse phase chromatography. The examples show that adjustments are easy and time savings of 50% or more can be realized.