ABSTRACT

Basic Information

Abstract Number: 2380 - 1
Author Name: James J Hickman - University of Central Florida
Session Title: Biosensing Devices for Neuron Mapping
Event Type: Organized Contributed Sessions
Event Title: Integration of CNS and PNS Components with Silicon Devices via Surface Microengineering for Neuronal Mapping Applications

Presider Name:Chenzhong Li
Affiliation:Florida International University

Date: Thursday, March 10, 2016
Start Time: 01:30 PM (Slot #1)
Location: B315

Abstract Content

One of the major obstacles hindering the development of an effective therapy for Amyotrophic Lateral Sclerosis, Alzheimer’s and other neurodegenerative diseases is the lack of valid, functional in vitro models. Our advancements in culturing human and animal neurons in a defined serum-free medium, suggest outstanding potential for answering questions related to maturation, aging, neurodegeneration and injury, as well as to screen different novel and putative drug candidates. The long-term research goal of our group is to learn how to handle and prepare cells to serve as components for microdevices and engineered tissues, and then to demonstrate the practicality of this approach by manipulating them to build hybrid systems and engineer functional tissues. The idea is to integrate microsystems fabrication technology and surface modifications with protein and cellular components, with the aim of initiating and maintaining self-assembly and growth into biologically, mechanically and electronically interactive functional multi-component systems. The HSL is using this ability to manipulate the biological components and integrate it with silicon-based systems to create cell-based sensors for high throughput drug discovery and functional genomic assays as well as for hybrid neuronal/silicon systems to study biological computation and neuronal mapping. We are also using what we learn for a more fundamental understanding of cellular development and neuronal regeneration. Finally, we believe our research is at the forefront of the next generation of Systems Biology tools necessary to establish the field as the predominant method utilized in drug discovery.