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ABSTRACT
Basic Information
Abstract Number: | 1800 - 7 |
Author Name: | Charles R Mace - Tufts University |
Session Title: | Ralph N Adams Award |
Event Type: | Awards |
Event Title: | Paper-Based Microfluidic Devices for Point-of-Need Bioanalysis |
Presider Name: | Norman J Dovichi | Co-Author: | Syrena C Fernandes, Samuel Berry |
Affiliation: | University of Notre Dame | Affiliation: | Tufts University |
Date: | Wednesday, March 9, 2016 |
Start Time: | 03:40 PM (Slot #7) |
Location: | B312 |
Abstract Content
We have developed a suite of three-dimensional paper-based microfluidic devices that enable diagnostic assays to be performed directly at the point-of-need. Paper offers a number of attractive characteristics that supports its use as a foundational platform for bioanalytical sensing in resource-limited settings: it is inexpensive, disposable, and compatible with an extensive range of chemical and biochemical reactions. The use of paper-based devices significantly reduces the burden of effort on an end-user, as complex biological samples (e.g., urine and blood) can be applied to the device directly without additional preparation and all biochemical reactions needed for an analysis (e.g., incubation with secondary antibodies) are performed autonomously within the device. Paper-based microfluidic devices thus permit many critical functions used by more sophisticated lab-on-a-chip technologies, but do not rely on power or additional instrumentation to provide valuable information on the health status of a patient. We have demonstrated our method by designing a general device architecture that is capable of performing immunoassays broadly, and we have expanded this approach to include multiplexed immunoassays. Further, we have demonstrated that the careful tuning of the physical and chemical properties of paper can enable entirely new classes of bioanalytical assays. Diagnostic assays created using simple and inexpensive materials have the potential to transform healthcare management systems in resource-limited settings. |
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