ABSTRACT

Basic Information

Abstract Number: 40 - 4
Author Name: Renă Robinson - University of Pittsburgh
Session Title: Emerging Leaders in Biological Mass Spectrometry
Event Type: Symposia
Event Title: Multi-Tier Approach to Understand the Biology of Alzheimer’s Disease

Presider Name:Amanda B Hummon
Affiliation:University of Notre Dame

Date: Sunday, March 6, 2016
Start Time: 02:45 PM (Slot #4)
Location: B302

Abstract Content

‘Omics-based approaches are increasingly being recognized for offering powerful ways to investigate biological processes, especially in the context of Alzheimer’s disease. Advances in mass spectrometry instrumentation and bioinformatics have increased the throughput with which we can begin to ask and answer difficult biological questions and study complex systems. There are many levels (i.e., epidemiological, clinical, genetic, proteomic, metabolomic, etc.) with which one can answer biological questions about Alzheimer’s disease, and each of these levels is important to guide research directions, facilitate hypothesis generation, and inform diagnostic or therapeutic strategies. Synthesizing information from these multiple levels however can be challenging due to the amount and complexity of the data that is generated, lack of tools for data integration, and missing pieces of data. This presentation will give examples of our multi-tier proteomics and information synthesis approach to understanding aspects of biology in Alzheimer’s disease.