Course Information
Course Title: Lab on a Chip Devices I
Categories: 1 - Life Sciences
2 - Biomedical Engineering
3 - Clinical Analysis
4 - Polymerase Chain Reaction
5 - Polymers
6 - Proteomics
7 - Environmental Analysis
8 - Flow Injection Analysis
9 - Sensors
10 - Homeland Defense
11 - Laboratory-on-a-chip/Microfluidics
Instructor(s): Oliver Geschke, Jaime Castillo Course Number: 82
Affiliation: Technical University of Denmark
Course Date: 03/11/2009 - Wednesday Course Length: 1/2 Day Course
Start Time: 08:30 AM End Time: 12:30 PM
Fee: $215 ($315 after 2/9/09) Textbook Fee: $135, same Text as Course 83

Course Description
Many of us own portable computers, telephones and audio/video equipment that did not exist a decade ago. The reason for this rapid change is that miniaturizing and integrating of electronic and electro¬mechanical components are still an ongoing processes. The general strategy to miniaturize and integrate can also be applied to other scientific fields such as chemistry and the life sciences. There is a vision that all stages of chemical analysis, such as preparing and purifying a sample, handling of liquids, detecting and analyzing a signal, will one day be integrated and automated on a single microsystem. The idea behind this vision is, that such a system is portable and delivers more and qualitative better data more rapidly than a conventional system, while using only very small amounts of the reagents. To realize such a system, components from different fields, such as electronics, optics, mechanics and fluidics, have to be miniaturized. The scope of this course is to give a common understanding on this interdisciplinary field. You will be introduced into the basics of microfluidics and various microfabrication methods (silicon and glass) will be presented. Simulation and modelling techniques of lab-on-a-chip systems will be taught as well. Examples from DTU Nanotech's research activities will be given and fabricated items will be on display during the course. This course will provide you with the basic theoretical understanding to proceed with course “Lab on a Chip devices II”. Textbook recommendation for both courses “Lab-on-a-chip devices I+II”: Microsystem Engineering of Lab-on a-chip Devices; Geschke, Klank, Telleman (Eds.), Wiley-VCH, 2004 ISBN# 3-527-30733-8

Target Audience
Anybody curious about Lab-on-a-chip devices – interdisciplinary course After following the courses “Lab-on-a-chip devices I + II”, the student will be able to design processes to fabricate simple lab-on-a-chip devices. Having built up the knowledge on microfluidics and microliquid handling, students are capable to predict flow behaviour in microfluidic devices to construct for instance micromixers and/or micropumps. The course participants will finally be able to discuss their individual “Lab-on-chip” challenges and identify the best solution.

Course Outline
General Introduction
Microfluidics  Simulation and Design  Microfabrication techniques (silicon + glass)
Examples

Course Instructor's Biography
Oliver Geschke graduated in Chemistry in 1994 at the University of Münster, Germany, where he also carried out his PhD theses. In December 1998 he joined the Department of Micro- and Nanotechnology (DTU Nanotech) at the Technical University of Denmark (DTU), Kgs. Lyngby, Denmark, where he worked first as an assistant professor on a European Project on wastewater analysers and in 2001 became Associated Professor. He is heading a research group “Polymeric Enabling Microsystems, POEM” and has been supervising and co-supervising a number of MSc and PhD students and postdoctoral researchers. Oliver has been Chief Editor on a textbook entitled “Microsystem Engineering of Lab-on-a-chip Devices”, that has been released in 2004 which serves as a backbone for this course. He has international teaching experience from courses in and outside the university and offers this Pittcon course this year in the 6th edition. Jaime Castillo graduated in Chemistry in 2000 at the Industrial University of Santander, Colombia. He joined the biosensor research group at the Biotechnology Department at Lund University, Sweden in 2001 where he carried out his PhD research entitled “Amperometric biosensors for detection of analytes in cellular models”. In 2006 he worked as a postdoctoral fellow at the Elektroanalytik & Sensorik group at the Analytical Chemistry Department at Bochum University, Germany, where he was working in the fabrication and development of biosensors for the detection of compounds of biomedical relevance in cells using Scanning Electrochemical Microscopy (SECM). In 2007 he joined the Micro and Nanotechnology Department, DTU Nanotech, at the Technical University of Denmark (DTU) as a postdoctoral researcher. At MIC he is member of the Nano Bio Integrated Systems group, NaBIS. Jaime has been supervising a co-supervising a number of master and PhD students. He has been involved in several European research projects, published several papers in various journals and international conference proceedings, and contributed to one textbook. His research focuses in the manipulation and integration of biological nanofibers and nanotubes into new innovative ways of designing and assembling man-made devices such as nanosensors or field effect transistors.