Course Information
Course Title: Lab-on-a-Chip Devices II
Categories: 1 - Life Sciences
2 - Biomedical Engineering
3 - Clinical Analysis
4 - Polymerase Chain Reaction
5 - Polymers
6 - Environmental Analysis
7 - Flow Injection Analysis
8 - Sensors
9 - Homeland Defense
10 - Laboratory-on-a-chip/Microfluidics
Instructor(s): Jaime Castillo Course Number: 83
Affiliation: DTU Nanotech
Course Date: 03/11/2009 - Wednesday Course Length: 1/2 Day Course
Start Time: 01:00 PM End Time: 05:00 PM
Fee: $215 ($315 after 2/9/09) Textbook Fee: $135, same text as Course 82

Course Description
Micro- and nanotechnology enables the fabrication of miniature electronic components and thereby functional integration of such components to form integrated circuits. This general strategy of miniaturization and functional integration can also be applied to other scientific fields such as chemistry anf the life sciences. In such micro Total Analysis Systems (microTAS) or Laboratories-on-Chips all component stages of chemical analysis like sample preparation, analyte purification, microliquid handling, analyte detection, and data analysis are to be performed in an integrated and automated fashion on microchip. The realization of such systems for bio/chemical analyses requires miniaturization and integration of a wide variety of components, i.e. mechanic, fluidic, optic, and electronic. Advantages of microTAS are portability, higher quality and quantity data, faster kinetics, automation, and reduction of sample and reagent volumes. Furthermore, micro- and nanotechnology opens up the possibility of new functions that cannot be realized with conventional techniques. In this workshop we will discuss the different stages of microTAS development, materials (silicon, plastic), microfabrication, microliquid handling components, back-end processing, functional integration, and applications in chemistry and biochemistry. These subjects will be illustrated with examples from research projects at the Department of Micro and Nanotechnology (DTU Nanotech) at the Technical University of Denmark. Textbook recommendation for both courses “lab-on-a-chip devices I + II”: Microsystem Engineering of Lab-on a-chip Devices; Geschke, Klank, Telleman (Eds.), Wiley-VCH, 2004, ISBN# 3-527-30733-8

Target Audience
Anybody curious about Lab-on-a-chip devices – interdisciplinary course After following the courses “Lab-on-a-chip devices I + II”, the student will be able to design processes to fabricate simple lab-on-a-chip devices. Having built up the knowledge on microfluidics and microliquid handling, students are capable to predict flow behaviour in microfluidic devices to construct for instance micromixers and/or micropumps. The course participants will finally be able to discuss their individual “Lab-on-chip” challenges and identify the best solution

Course Outline
Introduction
Microfabrication techniques (silicon + polymers) 
Microliquid handling components
Functional integration
Applications in Chemistry and the Life Sciences (state of the art)

Course Instructor's Biography
Jaime Castillo graduated in Chemistry in 2000 at the Industrial University of Santander, Colombia. He joined the biosensor research group at the Biotechnology Department at Lund University, Sweden in 2001 where he carried out his PhD research entitled “Amperometric biosensors for detection of analytes in cellular models”. In 2006 he worked as a postdoctoral fellow at the Elektroanalytik & Sensorik group at the Analytical Chemistry Department at Bochum University, Germany, where he was working in the fabrication and development of biosensors for the detection of compounds of biomedical relevance in cells using Scanning Electrochemical Microscopy (SECM). In 2007 he joined the Micro and Nanotechnology Department, DTU Nanotech, at the Technical University of Denmark (DTU) as a postdoctoral researcher. At DTU Nanotech he is member of the Nano Bio Integrated Systems group, NaBIS. Jaime has been supervising a co-supervising a number of master and PhD students. He has been involved in several European research projects, published several papers in various journals and international conference proceedings, and contributed to one textbook. His research focuses in the manipulation and integration of biological nanofibers and nanotubes into new innovative ways of designing and assembling man-made devices such as nanosensors or field effect transistors. Oliver Geschke graduated in Chemistry in 1994 at the University of Münster, Germany, where he also carried out his PhD theses. In December 1998 he joined the Department of Micro- and Nanotechnology (DTU Nanotech) at the Technical University of Denmark (DTU), Kgs. Lyngby, Denmark, where he worked first as an assistant professor on a European Project on wastewater analysers and in 2001 became Associated Professor. He is heading a research group “Polymeric Enabling Microsystems, POEM” and has been supervising and co-supervising a number of MSc and PhD students and postdoctoral researchers. Oliver has been Chief Editor on a textbook entitled “Microsystem Engineering of Lab-on-a-chip Devices”, that has been released in 2004 which serves as a backbone for this course. He has international teaching experience from courses in and outside the university.