Basic Information
Abstract Number: 330-3    
Author Name: Dakota O'Dell Affiliation: Cornell University
Session Title: Biomedical: Advances in Point-of-Care Technologies
Event Type: Oral Sessions
Event Title: A Smartphone Platform for Quantitative Point-of-Care Detection of Micronutrient Deficiencies
Presider(s): Culha, Mustafa Start Time: 09:10 AM ( Slot # 3 )
Date: Monday, March 7th, 2016 Location: B313
Keywords: Biomedical, Immunoassay, Lab-on-a-Chip/Microfluidics, Portable Instruments

Erickson, DavidCornel University
Hohenstein, JessicaCornell University
Lee, SeohoCornell University

Abstract Content
Micronutrient deficiencies are a “hidden hunger” which affect billions of people worldwide. According to the World Health Organization, vitamin A, zinc, and iron deficiencies are responsible for more than a million deaths annually. Nevertheless, micronutrient deficiencies are often asymptomatic and can be difficult to diagnose, particularly in the developing world where centralized medical infrastructure is limited. To address this need, we have developed the NutriPhone, a low-cost hardware device for point-of-care monitoring of micronutrients in whole blood which attaches directly to a smartphone. By using the smartphone camera as an optical sensor and a custom app for image processing, the NutriPhone device can quantitatively analyze rapid diagnostic test strips with no need for expensive laboratory devices or highly trained personnel. Hardware accessories are rapidly prototyped using 3D printing technology for multiple smartphone and tablet geometries. By modifying only the processing software, it is also possible to measure many different micronutrients and biomarkers with the same hardware accessory. To demonstrate this multiplexed capability, we evaluated the use of both smartphone and iPad devices on a number of test strips—both commercially available rapid diagnostic tests and custom strips developed in-house. We report on quantitative analysis of vitamins A, B12, and D, as well as other biomarkers including cholesterol, C reactive protein, and ferritin. Human field trials implementing the vitamin B12 test were also conducted at a rural clinic in Madanapalle, India.