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Short Course

Course Information
Course Title: Karl Fischer Analysis of Gas, Liquids and Solids
Categories: 1 - Petroleum Analysis
2 - Pharmaceutical Sciences
3 - Sample Preparation
4 - Food
5 - Infrared Spectroscopy
Instructor(s): Frederick Fiddler / Dr. Keith Freel / ; Dr. Tim Deschaines / Doug Clark Course Number: 93
Affiliation: Metrohm / Sigma Aldrich
Course Date: 03/06/2016 - Sunday Course Length: 1/2 Day Course
Start Time: 01:00 PM End Time: 05:00 PM
Fee: $300 ($400 after 2/12/16) Textbook Fee:

Course Description
Karl Fischer analysis spans many different industries such as; Food and Beverage, Pharmaceutical, Petrochemical, General Chemical among many others. No matter what industry you are associated with chances are Karl Fischer analysis is important to you. There can be many challenges encountered in Karl Fischer analysis ranging from; Side reactions, pH control and general sample preparation issues. This course focuses on the core principles of Karl Fischer analysis along with some key developments in; reagents, applications and instrumentation that address some of the challenges encountered in Karl Fischer analysis of different sample types.

Target Audience
Course focuses on defining the concepts in KF analysis and the challenges faced by industries and sample matrices. Practical approaches are discussed to address challenges with liquids gas and solids. This course is ideal for; laboratory technicians, Chemists, quality control personnel and all lab related functions that utilize the technique.

Course Outline
After attending this course you will learn how to minimize side reactions through the appropriate selection of reagents and working medium modifications, effect pH control, and a range of sample preparation and handling techniques to enhance the release of water for the Karl Fischer titration. Some sample preparation techniques covered in this course are; Karl Fischer Oven technique, Oil Evaporator, integrated homogenizer, and Gas delivery and analysis. The use of NIR spectroscopy along with conventional Karl Fischer technique will also be reviewed. Water shows a very strong absorption in the NIR and is there by the ideal analyte for this technology. Compared with traditional analytical techniques, NIR spectroscopy has many inherent advantages for moisture detection. It allows noninvasive and nondestructive analysis, and no reagents are used. Samples can be analyzed in situ through glass or plastic containers with minimal preparation. Simultaneous multi-component analysis is possible, and the total analysis time is typically less than one minute. Determination of water content in solid, liquid, tablet and gas samples can be done by NIR online or offline using a suitable fiber optic probe. Water contents down to 0.05 % can be determined accurately depending on the matrix.

Course Instructor's Biography
Doug Clark is currently the National Technical Specialist for HYDRANAL® at Sigma-Aldrich. He is the HYDRANAL° Technical Center in St. Louis. With over twenty five years of experience, the last sixteen years have been dedicated to Karl Fischer titration. Since Karl Fischer titration isn’t something taught in most schools in the US, Doug was fortunate to have worked directly with several of the world’s leading experts in Karl Fischer such as Mrs. Helga Hoffmann, Dr. Katrin Schöffski, and Mr. Thomas Wendt. Also, Dr. Eugen Scholz has been a most valuable resource. Dr. Hari Narayanan Seventeen years of experience in analytical chemistry with hands on experience on IR, Raman, NIR spectroscopy and Titration, Ion chromatography, Voltammetry, XRF and several other analytical techniques. Has more than six years of method development experience with NIR spectroscopy. He is presently the Product Manager at Metrohm NIRSystems. He received his B.Sc and M.Sc. in Chemsitry from the MK University and a Ph.D. in Analytical chemistry from University of Madras, India. Frederick Fiddler Frederick is presently the Director of Technical Support at Metrohm USA. He has over fourteen years experience in analytical chemistry spanning; Titrations, Voltammetry, XRF and INAA. For the past 11 years Frederick has worked with the Metrohm group to resolve Karl Fischer related applications across multiple industries. Frederick received his B.Sc in Pure and Applied Chemistry from the University of the West Indies, Jamaica.