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Short Course

Course Information
Course Title: Practical Comprehensive Multidimensional Gas Chromatography (GCxGC)
Categories: 1 - Mass Spectrometry
2 - Gas Chromatography
3 - Gas Chromatography-Mass Spectrometry
Instructor(s): Matthew Klee Course Number: 11
Affiliation: XO ASSOCIATES LLC
Course Date: 03/06/2017 - Monday Course Length: 2 Day Course
Start Time: 08:30 AM End Time: 05:00 PM
Course Date 2: 03/07/2017 - Tuesday    
Start Time: 08:30 AM End Time: 05:00 PM
Fee: $1100 ($1500 after 2/18/17) Textbook Fee:

Course Description
Comprehensive multidimensional gas chromatography was expected by many to greatly expand the ability of gas chromatography to provide chemical information about samples through significant increases in separation power (peak capacity). Despite the passage of time (the original patent from 1992 has now expired), this expectation has in most regards not been achieved. Many have spent significant time and money on systems yet have not recouped the investment in the form of significantly-improved analytical information. There are several reasons why the promise has not been fulfilled, including poor modulator design, but much of the limitation lies in poor understanding of fundamental principles of gas chromatography: column selection, instrument configuration, and method optimization. This course is designed for those contemplating or currently attempting to implement GCxGC methods. Attendees will be reminded of the fundamental principles of gas chromatography and gas chromatographic instrumentation and how they apply to successful GCxGC. Principles of operation of popular modulators will be reviewed and compared. Examples of good and bad implementation will be used to reinforce concepts. After completion of the course, attendees will be better informed when making decisions in buying, setting up, operating, and troubleshooting GCxGC instrumentation.

Target Audience
those contemplating or currently attempting to implement GCxGC methods

Course Outline
• Definitions
• Metrics of separation
• The Promise
• Modulator designs, history, evolution
• Column selectivity, column selection and pairing concepts
• Detector considerations, including MS
• Data mining, visualization, quantification

Course Instructor's Biography
Matthew S. Klee, PhD, is an internationally recognized analytical instrumentation expert, scientist, inventor, and author. He is considered one of the leading authorities in the areas of GC and GC-MS instrumental analysis. In addition, Dr. Klee is renowned for the quality and relevance of his live, on-line, and on-demand technical courses and presentations including GC and GC-MS related short courses at PittCon.