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Short Course

Course Information
Course Title: Pharmacokinetics and Pharmacodynamics for the Analytical Scientist
Categories: 1 - Life Sciences
2 - Clinical Analysis
3 - Pharmaceutical Sciences
4 - Data Analysis
5 - Sample Preparation
Instructor(s): Marcel Musteata Course Number: 46
Affiliation: Albany College of Pharmacy and Health Sciences
Course Date: 03/07/2017 - Tuesday Course Length: 1/2 Day Course
Start Time: 08:30 AM End Time: 12:30 PM
Fee: $325 ($425 after 2/18/17) Textbook Fee:

Course Description
The course will cover intermediate-level topics related to pharmacokinetics, pharmacodynamics, therapeutic drug monitoring, and applications of drug analysis in these areas. The principles of pharmacokinetics will be presented in relation to analytical chemistry, drug discovery, and evaluation of drug therapy. Course participants will learn to build pharmacokinetic models and derive corresponding equations by integration and Laplace transformation. These equations will be used to calculate specific pharmacokinetic parameters from patient data or from population data. These principles will be used to evaluate drug literature and develop drug dosage regimens. The course will consist of lectures, case based tutorials, and active learning.

Target Audience
- Analytical and bioanalytical scientists that analyze drugs in biological samples - Interdisciplinary scientists involved in drug discovery - Scientists that collaborate or work with pharmacokinetic-pharmacodynamic teams

Course Outline
Part I - Introduction
• What is pharmacokinetics and pharmacodynamics (PKPD)
• Routes of drug administration
• Sampling and sample analysis for PKPD studies
• PKPD modeling
Part II – Basic Pharmacokinetics
• Compartment models
• Intravenous bolus administration
• Intravenous infusion
• Drug elimination and clearance
• Pharmacokinetics of other routes of drug administration
• Multiple dosage regimens
• Nonlinear pharmacokinetics
Part III - Applications of Pharmacokinetics and Pharmacodynamics
• Bioavailability and bioequivalence
• Pharmacodynamics and Therapeutic drug monitoring
• Drug dosing regimens

Course Instructor's Biography
Dr. Marcel Musteata is an associate professor in the Department of Pharmaceutical Sciences at the Albany College of Pharmacy and Health Sciences (Albany, NY). He received his Pharm.D. degree from the Jassy University of Medicine and Pharmacy, his Ph.D. from the University of Waterloo, and postdoctoral training at the University of Toronto. Dr. Musteata specializes in the development of new analytical methods that address the specific needs of pharmacokinetic studies, and development of new pharmacokinetic models based on free drug concentrations. Most notably, he has developed nanoporous microextraction coatings for in vivo sampling, and a mathematical model for individualizing drug therapy based on body composition.