Short Course Listings
 
Short Course

Course Information
Course Title: LC-MS-MS Analysis of Emerging Contaminants (EDCs, PPCPs and PFCs) and Nanomaterials in the Environment
Categories: 1 - Liquid Chromatography-Mass Spectrometry
2 - Environmental Analysis
Instructor(s): Damia Barcelo Course Number: 15
Affiliation: ICRA
Course Date: 03/05/2017 - Sunday Course Length: 1/2 Day Course
Start Time: 08:30 AM End Time: 12:30 PM
Fee: $325 ($425 after 2/18/17) Textbook Fee:

Course Description
In this course you will learn about the various Liquid chromatography- tandem mass spectrometric (LC-MS-MS) methods used for the determination of endocrine disrupting compounds (EDCs) ,pharmaceuticals and personal care products (PPCPs), perfluorinated compounds (PFCs) and carbon-based nanomaterials in environmental samples. Compounds listed will be: steroid sex hormones, Pharmaceuticals such as antibiotics, ▀-blockers, anti-inflammatory drugs, lipid regulators, cyutostaics ,psychiatric drugs and illicit drugs, UV filter used as Personal Care Products as well as Perfluorinated compounds (PFCs) such as perfluoro- alkylcarboxylic acids, - sulfonates and -sulfonamides are listed too. Fullerenes were selected as target nanomaterials. LC-MS-MS has gained in popularity, due to the sensitivity, ruggedness and ease of use given by API interfaces, such as electrospray (ESI) and atmospheric pressure chemical ionization (APCI),atmospheric pressure photoinization interface (APPI) respectively combined with a new generation of MS equipment (QqQ, linear on-trap Q TRAP and time of flight Q TOF and Orbitrap Velos and Q Exactive). LC-MS-MS have become often routine methods for the 200 Emerging chemicals listed in this short course. Comparison of hybrid instruments like LC-Q-TOF-MS , Q-Orbitrap-Exactive and Q Trap LC-tandem MS for multi-residue analysis of emerging contaminants will also be reported

Target Audience
The course material should be of interest to environmental chemists, either doing a PhD or not, involved in method development, analytical chemists, laboratory personnel,and governmental and industry regulators. Participants should have some general knowledge of mass MS. It can be considered a course between intermediate and advanced level.

Course Outline
1. Introduction to EDCs and PFCs: general environmental problems, regulations in US and Europe, toxic effects, environmental levels.
2. Introduction to PPCPs and nanomaterials: use, general environmental problems, toxic effects, environmental levels
3. Sample preparation for solid (sludges, sediments, soils) and liquid samples (natural waters, wastewaters, drinking water) using off-line and on-line SPE techniques (Prospket, Equan, Symbiosis, Turboflow) and direct MS/MS introduction like DART and DESI.
4 LC-MS-MS , Q Trap LC- MS and LC(UPLC)-Q-TOF-MS and Orbitrap (Q Exactive and Velos) of polar EDCs ( synthetic and natural steroids, new brominated flame retardants HBCD) , PPCPs, PFCs and fullerenes (nanomaterials) .
5. Summary and comparison of the various MS techniques used for EDCs , PPCPs, PFCs and nanomaterials in terms of sample manipulation, sensitivity and cost of analysis. Case studies: Monitoring in natural waters , groundwaters, wastewaters and sediments.

Course Instructor's Biography
Professor Damia Barcelˇ. Graduate in Chemistry (1977) and Ph. D. (1984) in Analytical Chemistry from the University of Barcelona. Since 1999 full Research Professor at IDAEA-CSIC , Deputy director at IDAEA-CSIC, Barcelona, Spain since january2009 and Director of Catalan Institute for Water Research (ICRA) in Girona, Spain. (since may 2008). From December 2009 – 2014 Visiting professor at the King Saud University, Riyadh, Saudi Arabia. He has been a pioneer in the applications of LC/MS to environmental analysis, with the first publication in 1987 and a book in 1996. Publications: over 920 scientific papers in journals of the science citation index, 202 book chapters and co-author of 1 book on Pesticides analysis in the environment and editor of 30 books on Environmental analysis and fate of pollutants between 1993-2016,being the most recent ones : 2012. Emerging Organic Contaminants and Human Health Vol 20. The Handbook of Environmental Chemistry, Ed D Barcelo, 2012 Springer Verlag (Germany) pag 1-466. 2012 Analysis and Risk of Nanomaterials in Environmental and Food Samples”, Editors: DamiÓ Barcelˇ and Marinel.la FarrÚ. Elsevier (Comprehensive Analytical Chemistry series, vol 59 ) pag 1-362. 2013 Global Risk-Based Management of Chemical Additives II Vol 23. The Handbook of Environmental Chemistry, Ed. B.Bilitewski, RM Darbra and D. Barcelˇ Ed: Springer Verlag (Germany) pags 1-478. 2013. Emerging Organic Contaminants in Sludges Vol 24. The Handbook of Environmental Chemistry, Ed T. Vicent, G. Caminal, E. Eljarrat and D Barcelo, Springer Verlag (Germany) pag 1-280. 2013.Analysis , Removal, Effects and Risks of Pharmaceuticals in The Water Cycle. Occurrence and Transformation in the Environment Elsevier (Comprehensive Analytical Chemistry series, vol 62 ) Ed. Mira Petrovic ,DamiÓ Barcelˇ and Sandra PÚrez, pag 1-734. 2015. Personal Care Products in the Aquatic Environment Vol 36. The Handbook of Environmental Chemistry, Ed M.Silvia Diaz-Cruz and D Barcelˇ, Springer Verlag (Germany) pag 1-419. Emerging Contaminants in River Ecosystems Vol 46. The Handbook of 2016. Environmental Chemistry, Ed M.Petrovic, S.Sabater, A. Elosegui and D Barcelˇ, Springer Verlag (Germany) pag 1-220. 2016. Applications of Time-of-Flight and Orbitrap Mass Spectrometry in Environmental, Food, Doping and Forensic Analysis Elsevier (Comprehensive Analytical Chemistry series, vol 71 ) Ed. Sandra Perez, Peter Eichhorn and ,DamiÓ Barcelˇ, pag 1-480 Since January 2012, Co-Editor-In-Chief (EIC)of Science of the Total Environment (STOTEN) Elsevier, NL. Since 1997-up-to-date. EIC of the Wilson + Wilson Comprehensive Analytical Chemistry, book series (Elsevier, NL) Since 2007 Co-EIC of the Handbook of Environmental Chemistry book series (Springer-Verlag) Associate Editor of Trends in Analytical Chemistry (Elsevier, NL) and Environment International (Elsevier, NL) and member of the Editorial board of SCI journals Analytical Bionalytical Chemistry (Springer), and Methods X (Elsevier). The Hirsch-Index is 90 Included in the ISIHighlyCited. In the field of Ecology/Environment. Times cited: 38, 244 Average citation per item: 36, 22 Member of the Scientific Panel of the European Food Safety Authority (EFSA) (2004-2009) and Panel Member of the EURYI (European Young Investigator Awards) from ESF (2004-2007) Chairman of the Scientific and Technological Board (STB) of the EU-Joint Programming Initiative on “Water challenges for a changing World” from 2011-2015.. Prizes-Prize King Jaime I on the Protection of Nature 2007 from Generalitat of Valencia, Spain -Prince Sultan Bin Abdulaziz International Prize for Water (PSIPW) 5th Award 2012 on Water Management & Protection, Saudi Arabia -Recipharm Environmental Award 2012, Sweden Between (1992-2016) has supervised 48 Ph D thesis on environmental analysis of organic pollutants on water sediment and biota using mass spectrometric techniques, specially LC-MS and LC-MS-MS, immunoassay, toxic assays and biosensors. The course outlined above has been offered as half day course at the Pittsburgh conference in 2005 and 2006, as one day course in 2007,one and half day course in 2008 and one day course in 2009-2012. From 2013-2015 the course was accepted but it was cancelled because of less than 10 students. In 2016 it took place again as half day course. At present D Barcelˇ is also thecoordinator of two large European Union projects, GLOBAQUA and Sea-on –a-Chip . GLOBAQUA tackles the issue of analysis and fate of emerging contaminants and nanomaterials in European freshwaters resources. Sea-on-aChip project will develop a sensor to measure emerging sea contaminants in fish farms and coastal areas by a lab-on-a chip biosensor that will be validated by advanced mass spectrometric techniques.