Utilization of Newer LC and MS Technologies for Rapid Information Generation in Pharmaceutical Development
Tuesday, March 2nd, 2010
01:00 - 03:00 PM Room: 312B

Bryan C Castle and Todd Gillespie

The use of liquid chromatography (LC) and liquid chromatography/mass spectrometry (LC/MS) within the area of pharmaceutical analysis will be addressed. Areas of discussion will focus on the incorporation of sub-3 micron based stationary phases for rapid method development with UV and/or MS detection. Additionally, the open access environment will be reviewed and this discussion will include the use of LC/MS within product development (nominal mass and accurate mass), coupling new higher pressure LC instrumentation (UPLC and sub-3 micron columns) to MS instruments, the multi-mode and other ionization sources, and tandem MS instrumentation within an open access environment. Other topics open for discussion will be the types of software that are utilized to handle the growing amounts of data/information generated from LC and LC/MS systems and the potential use of MS instrumentation within the manufacturing environment. Issues and strategies around these topics will be discussed.