Basic Information
Abstract Number: 30-4    
Author Name: Zheng Ouyang Affiliation: Purdue University
Session Title: Advances in Hand-portable Ion Mobility and Ion Trap Chemical Analyzers
Event Type: Symposia
Event Title: Portable Mass Spectrometers vs. Portable Mass Spectrometry Analysis Laboratories
Presider(s): Lee, Milton L Start Time: 02:50 PM ( Slot # 5 )
Date: Sunday, February 28th, 2010 Location: 311A
Keywords: Analysis, Bioanalytical, Biomedical, Environmental

Cooks, R GrahamPurdue University
Huang, GuangmingPurdue University
Liu, JiangjiangPurdue University
Manicke, Nicolas EPurdue University
Wang, HePurdue University

Abstract Content
Mass spectrometry (MS) has been recognized as an analytical technique with high sensitivity and selectivity as well as wide applicability. The recent development of miniature mass spectrometers has been shown to have great potential for performing mass analysis in field with portable instruments of small size and low cost. In addition to the mass analysis, sample treatment, typically including sample preparation and separation, and data interpretation are important steps of the MS-based analysis procedure and also require additional specialized equipment and operation. To allow in-situ chemical analysis to be practically implemented using mass spectrometry, the simplification of the full analysis procedure and the miniaturization of the entire system are highly desirable. This is also critical for the future development of MS analytical consumer products that can be easily operated in field by personnel with minimum specialized training for mass spectrometry. In this presentation, the development of MS analysis procedures requires simple or no sample treatment will be reported. Applications of the miniature MS systems for air monitoring, food safety and biomedical diagnosis have been developed with technologies including discontinuous atmospheric pressure interface (DAPI), desorption electrospray ionization (DESI), low temperature plasma (LTP) probe, and paper spray. Analysis examples include the detection of benzenes in air at sub-ppb concentration levels, melamine in raw milk products with a limit of detection as low as 0.25 ng/g, and pharmaceutical drugs in raw blood samples at their therapeutic concentration ranges.