Basic Information
Poster Number: 860-2    
Author Name: William J Long Affiliation: Agilent Technologies
Session Title: Pharmaceutical LC, HILIC and GPC I
Event Type: Poster
Event Title: Compendial Methods Adjusted to Use Non C18, or Non Reverse Phase with Superficially Porous Columns
Presider(s):   Start Time: ( Slot # 2 )
Date: Monday, March 12th, 2012 Location: Red Area on Exposition Floor, Aisles 1300-1500
Keywords: Chromatography, Drugs, HPLC, Liquid Chromatography

Joseph, MaureenAgilent Technologies
Link, JasonAgilent Technologies
Mack, AnneAgilent Technologies

Abstract Content
Higher productivity is the new catch phrase in pharmaceutical and other industries. One way to meet this demand is utilizing Superficially Porous HPLC columns such as Poroshell 120 into Compendial methods. These 2.7 um particles show comparable efficiency to sub 2 micron particles with about half the back pressure. Columns packed with these materials can be used in older HPLC instruments or in new higher pressure instruments for high resolution in longer column format. Previous work has utilized C18 reverse phase chromatography. In this work USP (United States Pharmacopeia) methods for generic pharmaceuticals will be adjusted to use non C18 Superficially Porous Columns or non reverse phase chromatography. The examples show that adjustments are easy and time savings of 50% or more can be realized.