Basic Information
Abstract Number: 2270-4    
Author Name: Zhan Shu Affiliation: University of Pittsburgh
Session Title: Analysis of Neurochemical Systems II
Event Type: Oral
Event Title: The Heterogeneity of Evoked Dopamine Release in the Rat Nucleus Accumbens Core
Presider(s): Johnson, Michael Start Time: 09:00 AM ( Slot # 4 )
Date: Thursday, March 15th, 2012 Location: 311B
Keywords: Bioanalytical, Electrochemistry, Neurochemistry, Voltammetry

Michael, Adrian CUniversity of Pittsburgh

Abstract Content
Electrically evoked dopamine release has been measured with in vivo voltammetry in the rat striatum and nucleus accumbens. In previous studies our group has demonstrated the heterogeneity of evoked dopamine release in the rat striatum and attributed the heterogeneous release profile to the tonic autoinhibition of dopamine terminals. In this study, we found that the evoked dopamine release in the nucleus accumbens is also heterogeneous in both amplitude and temporal profile. Moreover, difference in the kinetic profiles of dopamine releases in those two regions has been analyzed, and we attributed it to the difference of dopamine transporter in the rat striatum and nucleus accumbens. (National Institutes of Health grant #MH075989)