Nitroxide Spin Labels in NMR and ESR Studies of Protein
Wednesday, March 14th, 2012
2:00 PM Room: 207A
Sunil Saxena, University of Pittsburgh
The use of site-directed spin-labeling has revolutionized the use of ESR and NMR to provide exciting new methodologies for measuring folding patterns and conformational dynamics in proteins inaccessible by other biophysical methods. The talks will highlight the applications in systems such as membrane proteins, ion-channels, misfolded or fibrillar proteins. The symposium will also present new methodology for the quantification of local dynamics, large distances, as well as novel hyperpolarization methods to enhance the signal in NMR by the use of nitroxide spin labels.