Addressing Challenges in Dietary Supplement Analysis
Wednesday, March 14th, 2012
8:00 AM Room: 313
Catherine A Rimmer, National Institute of Standards and Technology and R Kenneth Marcus, Clemson University
At least 65 % of adults in the U.S. consider themselves dietary supplement users (vitamin, mineral, and botanical) resulting in estimated annual expenditures of $25 billion U.S. dollars (Nutraceuticals World, April 2010) despite occasional publicity regarding dietary supplement mislabeling or contamination. Accurate and precise methods for determination of active/marker compounds and potential contaminants are essential in the analysis of dietary supplements. The measurements play an important role in assessing the composition of materials used in clinical trials, as well as to help ensure the health and safety of consumers. Additionally, the Food and Drug Administration (FDA) requires all dietary supplement manufacturers to comply with current Good Manufacturing Practices (cGMPs), which include the implementation of appropriate analytical methods to ensure product quality at every stage of processing. Analysis of dietary supplements is challenging for several reasons: the matrices themselves are often complex and it is not unusual for there to be multiple botanical extracts in one finished product; extensive extraction studies are necessary; the levels of the target analytes vary significantly (within and between products); and target analytes vary in stability requiring special sample handling. The speakers in this symposium will address different approaches to the analysis of dietary supplements including extraction, chromatographic separation, detection, and the development and appropriate use of reference materials.